Promising galactose-decorated biodegradable poloxamer 188-PLGA diblock copolymer nanoparticles of resibufogenin for enhancing liver cancer therapy

Encapsulation of Curcumin in Diblock Copolymer Micelles for Cancer Therapy

Application of nanoparticles has recently promising results for water insoluble agents like curcumin. In this study, we synthesized polymeric nanoparticle-curcumin (PNPC) and then showed its efficiency, drug loading, stability, and safety. Therapeutic effects of PNPC were also assessed on two cell lines and in an animal model of breast cancer. PNPC remarkably suppressed mammary and hepatocellul...

synthesis of peg-plga copolymer for preparation of docetaxel nanoparticles

Preparation and in vivo evaluation of insulin-loaded biodegradable nanoparticles prepared from diblock copolymers of PLGA and PEG.

The aim of this study was to design a controlled release vehicle for insulin to preserve its stability and biological activity during fabrication and release. A modified, double emulsion, solvent evaporation, technique using homogenisation force optimised entrapment efficiency of insulin into biodegradable nanoparticles (NP) prepared from poly (DL-lactic-co-glycolic acid) (PLGA) and its PEGylat...

Amphiphilic Diblock Copolymer Surface

10 11 Both visible and infrared (IR) spectroscopic ellipsometry have been employed to study the 12 structure of thin layers of bovine submaxillary mucin (BSM) adsorbed on poly(acrylic acid13 block-methyl methacrylate) (PAA-b-PMMA) copolymer and poly(methyl methacrylate) 14 surfaces at three pH values (3, 7 and 10). The adsorbed mucin layer on the copolymer surface 15 had the greatest thickness ...

Biodegradable Nanoparticles for Intra-articular Therapy

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive loss of articular cartilage which leads to severe pain and restricted mobility in the patients. Age, excessive joint loading, or sports injury are the factors known to increase the risk of joint degeneration thus leading to OA. Many techniques have been employed in OA therapy but none of them has given sati...